Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG

摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sex Hormone Binding Globulin (SHBG), in particular, by targeting natural antisense polynucleotides of Sex Hormone Binding Globulin (SHBG). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SHBG.

主权项

1. A method of upregulating a function of and/or the expression of a Sex Hormone Binding Globulin (SHBG) polynucleotide having SEQ ID NO: 1 in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide is specific for a natural antisense polynucleotide of the SHBG gene having SEQ ID NOS: 2 or 3 and has at least 80% sequence identity to a reverse complement of a polynucleotide comprising 12 to 30 consecutive nucleotides within nucleotides 1 to 3016 of SEQ ID NO: 2 or nucleotides 1 to 1609 of SEQ ID NO: 3; thereby upregulating a function of and/or the expression of the Sex Hormone Binding Globulin (SHBG) polynucleotide in patient cells or tissues in vivo or in vitro.