Arylethynyl pyrimidines

摘要

The present invention relates to ethynyl derivatives of formula I;
wherein
R1 is hydrogen or halogen;R2 is C1-3-alkyl or —(CH2)n—O—CH3;n is 2 or 3;m is 1 or 2;

or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.
;It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) with improved properties for the treatment of schizophrenia, cognitive diseases, fragile X syndrome or autism.

主权项

1. An ethynyl derivative of formula I wherein R1 is hydrogen or halogen; R2 is C1-3-alkyl or —(CH2)n—O—CH3; n is 2 or 3; m is 1 or 2; or a pharmaceutically acceptable acid addition salt and/or optical isomer and/or stereoisomer thereof.