Methods and compositions for the treatment of cancer or other diseases

摘要

The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function. More particularly, the present invention relates to multifunctional molecules that are capable of being delivered to cells of interest for the treatment of diseases and for the improvement in immune function.

主权项

1. An oligonucleotide comprising a modified human STAT3 sense strand comprising an oligonucleotide having the nucleotides set forth in SEQ ID NO:17, wherein nucleotides at positions 3, 4, 7, 9, 10, 12-4, 16-19 and 23 are modified and wherein the modifications are independently selected from the group consisting of a 2′-alkyl pyrimidine, 2′F, 2′OMe, amino, a deoxynucleotide, an abasic sugar, a 2-O-alkyl modified pyrimidine, 4-thiouracil, 5-bromouracil, 5-iodouracil, 5-(3-aminoallyl)-uracil and LNA.