发明名称 |
FAS-chimera adenovirus vector |
摘要 |
The invention provides methods of reducing or decreasing a size of a tumor or eliminating a tumor or inhibiting, decreasing, or reducing neo-vascularization or angiogenesis in a tumor in a patient by administering an adenovirus comprising a nucleic acid construct comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter. Also provided is a homogeneous population of an adenovirus comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter and its uses thereof. |
申请公布号 |
US9200056(B2) |
申请公布日期 |
2015.12.01 |
申请号 |
US201414527667 |
申请日期 |
2014.10.29 |
申请人 |
Vascular Biogenics Ltd. |
发明人 |
Breitbart Eyal;Leubitz Andrea;Feige Erez;Penson Richard |
分类号 |
A61K35/00;A01N63/00;C12N15/00;C07K14/705;A61K35/761;A61K48/00;A61K31/337;A61K31/713;A61K45/06;C12N7/00 |
主分类号 |
A61K35/00 |
代理机构 |
Sterne, Kessler, Goldstein & Fox P.L.L.C. |
代理人 |
Sterne, Kessler, Goldstein & Fox P.L.L.C. |
主权项 |
1. A vector comprising the sequence set forth in nucleotides 1 to 35207 of SEQ ID NO: 19. |
地址 |
Or Yehuda IL |