Process for the preparation of (R)-N-benzyl-2-acetamido-3-methoxypropionamide

摘要

The invention is a novel process for the preparation of lacosamide by employing novel intermediates of formula III and IV:;

主权项

1. A process for the preparation of lacosamide comprising of:
i)treating the compound of formula IA with N-protecting groups to obtain the compound of formula II wherein P is an N-protecting group; ii) treating the compound of formula II with 2,2-dimethoxy propane in the presence of an acid to obtain a compound of formula III; iii) treating the compound of formula III with benzylamine in the presence of a suitable base and an carboxyl activator to obtain a compound of formula IV; iv) deprotecting the compound of formula IV to obtain a compound of formula V; v) treating the compound of formula V with an acetylating agent to obtain a compound of formula VI; vi) treating the compound of formula VI with a methylating agent to obtain lacosamide.