Methods of treating diabetes using therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptides

摘要

The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistance in the body, solubility, and bioavailability.

主权项

1. A method of treating diabetes in a subject in need thereof, comprising administering an effective amount of a therapeutic agent,
wherein said therapeutic agent comprises an elastin-like peptide (ELP) and a glucagon-like peptide (GLP)-1 receptor agonist, wherein the ELP comprises at least one repeating unit selected from SEQ ID NOs: 1-12.