Protein

摘要

The present invention provides methods and compositions for screening, diagnosis and prognosis of colorectal cancer, kidney cancer, liver cancer, lung cancer, lymphoid leukaemia (particularly chronic lymphocytic leukaemia), ovarian cancer or pancreatic cancer, for monitoring the effectiveness of colorectal cancer, kidney cancer, liver cancer, lung cancer, lymphoid leukaemia (particularly chronic lymphocytic leukaemia), ovarian cancer or pancreatic cancer treatment, and for drug development.

主权项

1. A method comprising administering to a patient having a cancer in which OGTA076 is overexpressed in cancer tissue as compared to healthy control tissue a composition comprising an antibody or an antigen-binding fragment thereof that specifically binds to OGTA076 isoforms as defined in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, wherein said antigen-binding fragment is conjugated to a therapeutic moiety, and a pharmaceutically acceptable diluent or carrier, wherein the cancer is liver cancer, lung cancer, chronic lymphocytic leukaemia, ovarian cancer, or pancreatic cancer and the administering treats the patient with the cancer.