| 发明名称 | PAMAM, spacer molecule and cafestol polymers | ||
| 摘要 | The present invention is directed to a polymeric compound with a size in a nanometric scale, useful as a biocompatible carrier for the transport and delivery of active agents into a fish, insect, animal, reptile, bird, human, or plant, wherein said polymeric compound comprises PAMAM (polyamidoamine) dendrimers, a spacer molecule, and cafestol, wherein the polymeric compound of the invention comprises a structure of the kind (cafestol-PAMAM derivative)2-spacer molecule. Use of the compound as a biocompatible carrier for transport and delivery of antithrombotic active agents is disclosed. Procedures for obtaining a polymeric compound comprising the activation of cafestol, activation of polyethylene glycol, and formation of cafestol-PAMAM-PEG-PAMAM-cafestol are also disclosed. | ||
| 申请公布号 | US9198973(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201313919403 | 申请日期 | 2013.06.17 |
| 申请人 | Fundacion Fraunhofer Chile Research;Universidad de Talca | 发明人 | Santos Leonardo S.;Amalraj John;Duran Lara Esteban F.;Nachtigall Fabiane M. |
| 分类号 | A61K47/00;C08L77/00;C08L79/00;A61K47/48;C08L79/02 | 主分类号 | A61K47/00 |
| 代理机构 | Merchant & Gould P.C. | 代理人 | Merchant & Gould P.C. |
| 主权项 | 1. A nanoscale polymeric compound for use as a biocompatible carrier for the transport and delivery of a drug, protein, peptide or nucleic acid in a fish, insect, animal, reptile, bird, human, or plant in need thereof, wherein the polymeric compound comprises cafestol conjugated with a PAMAM (polyamidoamine) dendrimer, and a spacer molecule, in the following configuration: (cafestol-PAMAM)-spacer molecule-(PAMAM-cafestol); wherein the spacer molecule is selected from the group consisting of polyethylene glycol (PEG), polyethylene oxide, polyethylene, and polypropylene polyurethane. | ||
| 地址 | CL | ||