| 发明名称 | Yeast-Brachyury immunotherapeutic compositions | ||
| 摘要 | Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury. | ||
| 申请公布号 | US9198941(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201313803719 | 申请日期 | 2013.03.14 |
| 申请人 | The United States of America, as represented by the Secretary, Dept. of Health and Human Services;GlobeImmune, Inc. | 发明人 | Palena Claudia;Guo Zhimin;Apelian David;Schlom Jeffrey |
| 分类号 | A61K39/00;A61K39/385;A61K39/39;A61K36/06;A61K36/064;A61K38/17 | 主分类号 | A61K39/00 |
| 代理机构 | Sheridan Ross P.C. | 代理人 | Sheridan Ross P.C. |
| 主权项 | 1. A yeast-Brachyury immunotherapeutic composition comprising: (a) a whole, inactivated yeast; and (b) a Brachyury fusion protein comprising the amino acid sequence of positions 2-435 of SEQ ID NO:6 or the amino acid sequence of positions 2-435 of SEQ ID NO:18; wherein the Brachyury fusion protein is expressed by the yeast; and wherein the composition elicits a Brachyury-specific T cell response. | ||
| 地址 | Washington DC US | ||