Diagnostic assays and kits for detection of folate receptor 1

摘要

The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.

主权项

1. An antibody or antigen-binding fragment thereof that specifically binds to the same FOLR1 epitope as, and competitively inhibits the binding to FOLR1 of, an antibody selected from the group consisting of:
(a) an antibody comprising the variable heavy chain polypeptide of SEQ ID NO:25 and the variable light chain polypeptide of SEQ ID NO:29; (b) an antibody comprising the variable heavy chain polypeptide of SEQ ID NO:26 and the variable light chain polypeptide of SEQ ID NO:30; (c) an antibody comprising the variable heavy chain polypeptide of SEQ ID NO:27 and the variable light chain polypeptide of SEQ ID NO:31; and (d) an antibody comprising the variable heavy chain polypeptide of SEQ ID NO:28 and the variable light chain polypeptide of SEQ ID NO:32.