发明名称 Methods for the treatment of cardiovascular conditions
摘要 Provided herein are methods and systems for the treatment of cardiovascular conditions, including pulmonary hypertension (PH), in subjects that are being treated with a treatment regimen that includes a phosphodiesterase-5 (PDE-5) inhibitor.
申请公布号 US9198908(B2) 申请公布日期 2015.12.01
申请号 US201414216582 申请日期 2014.03.17
申请人 ST. JUDE MEDICAL LUXEMBOURG HOLDINGS II S.A.R.L. (“SJM LUX II”) 发明人 Yadav Jay
分类号 A61K31/495;A61K31/4985;A61K31/519;A61B5/00;A61B5/0215 主分类号 A61K31/495
代理机构 代理人
主权项 1. A method for treating a subject having a cardiovascular condition, comprising: (a) administering to the subject a treatment regimen that includes a PDE-5 inhibitor, wherein the PDE-5 inhibitor is selected from tadalafil or sildenafil; (b) obtaining one or more pulmonary arterial (PA) hemodynamic readings from the subject using an implantable pressure sensor, wherein the PA hemodynamic readings comprise a PA hemodynamic waveform; (c) processing the PA hemodynamic waveform using the processor of a computing device to obtain a cardiovascular parameter, wherein the cardiovascular parameter is selected from the group consisting of pulmonary arterial pressure (PAP), cardiac output (CO), peripheral vascular resistance (PVR), total peripheral resistance (TPR), heart rate, respiratory rate, dicrotic notch information, or combinations thereof; (d) comparing the cardiovascular parameter obtained from the subject to a standard to determine the efficacy of the treatment regimen for the treatment of the cardiovascular condition in the subject; and (e) maintaining or altering the treatment regimen administered to the subject in view of the indicated efficacy of the treatment regimen for the treatment of the cardiovascular condition in the subject.
地址 Luxembourg LU