Cyclosporine analogue molecules modified at amino acid 1 and 3

摘要

Analogs of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-A, and reduced immunosuppressivity in comparison with cyclosporin-A and analogs thereof modified solely at position 1.;

主权项

1. A compound of Formula L:wherein:
R′ is H or acetyl; R1 is a saturated or unsaturated straight chain or branched aliphatic carbon chain from 2 to 15 carbon atoms in length; R2 is a N-substituted or unsubstituted acyl protected amine; and R23 is methyl or ethyl.