Methods and compositions involving fibrillizing polypeptides for nanofibers

摘要

Embodiments of the invention are directed to fibrillar adjuvants. For example, epitopes assembled by a synthetic peptide domain into nanofibers comprising a β-fibrillization peptide may elicit high antibody titers in the absence of any adjuvant. In certain embodiments, multiple different antigens may be integrated into polypeptide nanofibers, providing biomaterials with modular and precise composition of bioactive proteins.

主权项

1. A nanofiber complex composition, wherein the composition comprises a β-sheet nanofiber structure comprising
a) a plurality of non-β-sheet peptide tags that undergo a transition from a non-β-sheet structure to a β-sheet structure in the presence of β-sheet peptides, wherein a non-β-sheet peptide tag is attached to a compound; and b) a plurality of β-sheet peptides.