N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or pharmaceutically acceptable salt thereof, and composition containing same as active ingredient for preventing or treating cancer

摘要

Disclosed herein are a new N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidin-2,4-diamine derivative or a pharmaceutically acceptable salt thereof and a pharmaceutical composition for the prevention or treatment of cancers containing the same as an active ingredient. The compound of the present invention has excellent inhibitory effects against the activities of anaplastic lymphoma kinase (ALK) and activated cdc42-associated kinase (ACK1) and thus can improve the therapeutic effects on the treatment of cancer cells having anaplastic lymphoma kinase fusion proteins such as EML4-ALK and NPM-ALK, and also effectively prevent the recurrence of cancers thus being useful as a pharmaceutical composition for the prevention and treatment of cancers.

主权项

1. An N2,N4-bis(4-(piperazin-1-yl)phenyl)pyrimidin-2,4-diamine derivative represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof: (in Chemical Formula 1, R1 and R2 are independently H, halogen, —OR6 or —NR7R8, where R6 is C1-C4 linear or branched alkyl unsubstituted, or substituted with at least one selected from the group consisting of halogen and C5-C6 aryl, R7 and R8 are independently H, C1-C4 linear or branched alkyl, C1-C4 linear or branched alkylcarbonyl or C5-C6 aryl; R4 and R5 are independently H; C1-C4 linear or branched alkyl unsubstituted or substituted with hydroxy group; —C(═O)R9 or —SO2—R10, where R9 is C1-C4 linear or branched alkyl unsubstituted or substituted with hydroxy group; C1-C4 linear or branched alkyloxy; amino unsubstituted or substituted with C1-C4 linear or branched alkyl, and R10 is C1-C4 linear or branched alkyl; amino unsubstituted or substituted with C1-C4 linear or branched alkyl, and R3 is halogen; or C1-C4 linear or branched alkyl substituted with at least one halogen).