发明名称 |
SSX-2 peptides presented by HLA class II molecules |
摘要 |
The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene. |
申请公布号 |
US9200047(B2) |
申请公布日期 |
2015.12.01 |
申请号 |
US201113028953 |
申请日期 |
2011.02.16 |
申请人 |
Ludwig Institute for Cancer Research, Ltd. |
发明人 |
Valmori Danila;Ayyoub Maha |
分类号 |
A61K38/00;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
Wolf, Greenfield & Sacks, P.C. |
代理人 |
Wolf, Greenfield & Sacks, P.C. |
主权项 |
1. An isolated nucleic acid molecule encoding an SSX-2 HLA class II-binding peptide comprising an endosomal targeting signal, wherein the SSX2 HLA class II-binding peptide consists of an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7 and SEQ ID NO:8. |
地址 |
New York NY US |