发明名称 |
Flow control device for assays |
摘要 |
The present disclosure relates to devices and methods for detecting the presence of a target analyte in a fluid sample using an assay. A fluidic device for flow control in an assay is disclosed comprising a water impermeable substrate (300) with a flow channel (301) located on its upper surface; a porous reagent pad (305) located within the flow channel, where the reagent pad includes a release zone that comprises a mobilizable reagent component of an assay; a porous sensor membrane (306) located within the flow channel downstream from the reagent pad, where the sensor membrane is separated from the reagent pad by a free space diffusion zone and where the sensor membrane includes a capture zone that comprises an immobilized capture component of the assay; a water impermeable top support located within the flow channel and disposed over at least a portion of the sensor membrane; and a flow control medium that forms a water impermeable seal around a portion of the top support and sensor membrane, where the seal is configure to direct flow of fluid into the sealed portion of the sensor membrane. |
申请公布号 |
US9199232(B2) |
申请公布日期 |
2015.12.01 |
申请号 |
US201113639430 |
申请日期 |
2011.04.06 |
申请人 |
Biosensia Patents Limited |
发明人 |
Flavin Diarmuid;Moynihan Shane;Kruger Jan;Walsh Jim |
分类号 |
B01L3/00 |
主分类号 |
B01L3/00 |
代理机构 |
Choate, Hall & Stewart LLP |
代理人 |
Choate, Hall & Stewart LLP |
主权项 |
1. A fluidic device for flow control in an assay comprising:
a water impermeable substrate with a flow channel located on its upper surface; a porous reagent pad located within the flow channel, where the reagent pad includes a release zone that comprises a mobilizable reagent component of an assay; a porous sensor membrane located within the flow channel downstream from the reagent pad, where the sensor membrane is separated from the reagent pad by a free space diffusion zone and where the sensor membrane includes a capture zone that comprises an immobilized capture component of the assay; a water impermeable top support located within the flow channel and disposed over at least a portion of the sensor membrane; and a flow control medium that forms a water impermeable seal around a portion of the top support and sensor membrane, where the seal is configured to direct flow of fluid into the sealed portion of the sensor membrane. |
地址 |
Dublin IE |