| 发明名称 | Recombinant bacterium comprising a toxin/antitoxin system | ||
| 摘要 | The present invention encompasses recombinant bacteria suitable for live attenuated vaccines, and methods of use thereof. One aspect of the present invention encompasses a recombinant Salmonella bacterium. The bacterium comprises a first promoter operably linked to a nucleic acid encoding a toxin and a second promoter operably linked to a nucleic acid encoding an antitoxin, wherein the second promoter is inactive in vivo, but active in vitro. | ||
| 申请公布号 | US9198950(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201113989692 | 申请日期 | 2011.11.22 |
| 申请人 | Arizona Board of Regents on behalf of Arizona State University | 发明人 | Mellata Melha |
| 分类号 | A61K39/112;A61K39/02;A61K49/00;A61K38/16;C12N1/38;C12N15/74;A61K39/00 | 主分类号 | A61K39/112 |
| 代理机构 | Polsinelli PC | 代理人 | Riley-Vargas Rebecca C.;Polsinelli PC |
| 主权项 | 1. A recombinant Salmonella bacterium, the bacterium comprising a first promoter operably linked to a nucleic acid encoding a toxin and a second regulatable promoter operably linked to a nucleic acid encoding an antitoxin, such that transcription of the nucleic acid encoding the antitoxin occurs in a permissive in vitro environment, but ceases in a non-permissive in vivo environment. | ||
| 地址 | Tempe AZ US | ||