| 发明名称 | KRT19 stabilizing HER2 and use thereof | ||
| 摘要 | Provided is a method of decreasing the stability of HER2 (human epidermal growth factor receptor 2) in a cell or individual comprising administering an effective amount of an expression or activity inhibitor of KRT19 (cytokeratin 19) to the cell or individual. | ||
| 申请公布号 | US9201061(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201313777501 | 申请日期 | 2013.02.26 |
| 申请人 | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY | 发明人 | Shin In-Cheol;Lee Tae-Hoon;Ju Ji-Hyun;Lee Kyung-Min;Yang Won-Seok |
| 分类号 | A61K31/70;A61K39/395;G01N33/50;A61K31/713;C12N15/113;C07K16/18;C12Q1/68;A61K39/00 | 主分类号 | A61K31/70 |
| 代理机构 | Mayer & Williams PC | 代理人 | Wieczorek Ann;Mayer & Williams PC |
| 主权项 | 1. A method of decreasing the stability of HER2 (human epidermal growth factor receptor 2) in an individual having a HER2-positive cancer comprising: administering an effective amount of an expression or activity inhibitor of KRT19 (cytokeratin 19) to the individual, wherein the activity inhibitor of KRT19 is an antibody which binds specifically to KRT19 protein. | ||
| 地址 | Seoul KR | ||