| 发明名称 | Inositol hexakisphosphate analogs and uses thereof | ||
| 摘要 | Provided herein are analog and derivative compounds of inositol hexakisphosphate effective to treat a Clostridium difficile infection and to neutralize the bacterial toxins produced by the same. In addition, methods of treating the C. difficile infection and for neutralizing its toxins with the compounds are provided. | ||
| 申请公布号 | US9200015(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201314052994 | 申请日期 | 2013.10.14 |
| 申请人 | The Board of Regents of the University of Texas Systems | 发明人 | Savidge Tor C.;Urvil Petril;Nauduri Dhananjaya;Oezguen Numan;Schein Catherine;Braun Werner |
| 分类号 | C07F9/117;C07F9/177;C07F9/06;C07F9/70 | 主分类号 | C07F9/117 |
| 代理机构 | Norton Rose Fulbright US LLP | 代理人 | Norton Rose Fulbright US LLP |
| 主权项 | 1. A method for neutralizing a Clostridium difficile bacterial toxin, comprising contacting the C. difficile bacterial toxin with an inositol hexakisphosphate analog having a chemical structure of Formula I:wherein R1, R2, R3, R4, R5, and R6 are —PS(OH)2. | ||
| 地址 | Austin TX US | ||