Use of an influenza virus or antigenic preparation thereof from a first influenza strain and an oil-in- water emulsion adjuvant in the preparation of an immunogenic composition for protection against influenza infections caused by a variant influenza strain wherein said oil-in-water emulsion comprises a squalene, alpha-tocopherol and an emulsifying agent

摘要

The present invention relates to influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in medicine, in particular their use in augmenting immune responses to various antigens, and to methods of preparation. In particular, the invention relates to multivalent influenza immunogenic compositions comprising an influenza antigen or antigenic preparation thereof from at least two influenza virus strains, at least one strain being associated with a pandemic outbreak or having the potential to be associated with a pandemic outbreak, in combination with an oil-in-water emulsion adjuvant.