Fumaric acid amides

摘要

Fumaric acid amides of the general formula (I) wherein R¹ represents OR³ or a D- or L-amino acid radical -NH-CHR⁴-COOH bonded via an amide bond, wherein R³ is hydrogen, a straight-chained or branched, optionally substituted C_1-24 alkyl radical, a phenyl radical or C_6-10 aralkyl radical and R⁴ is a side chain of a natural or synthetic amino acid and R² represents a D- or L-amino acid radical -NH-CHR⁵-COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R⁵ is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.