发明名称 |
Process for producing pharmaceutical intermediers |
摘要 |
The invention relates to a process for the preparation of compounds of general formula (III), wherein R represents fluorine or chlorine atom and X represents chlorine or bromine atom, by halogenation of cyclopropyl benzyl ketone of general formula (II), wherein R represents fluorine or chlorine atom and the halogenation is carried out in the mixture of aqueous hydrogen halide and aqueous hydrogen peroxide in the presence of a water miscible solvent or in the presence of a phase transfer catalyst; or the halogenation is carried out in the mixture of sulfuric acid and an alkali metal salt of aqueous hydrogen halide. The process can be applied preferably on industrial scale. |
申请公布号 |
HU230261(B1) |
申请公布日期 |
2015.11.30 |
申请号 |
HU20070000757 |
申请日期 |
2007.11.27 |
申请人 |
EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZVENYTARSASAG |
发明人 |
MEZEI TIBOR;LUKACS GYULA;MOLNAR ENIKOE;BARKOCZY JOZSEF;VOLK BALAZS;PORCS-MAKKAY MARTA;SZULAGYI JANOS;VAJJON MARIA |
分类号 |
C07C45/63;C07C49/567;C07D495/04 |
主分类号 |
C07C45/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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