SOLUBILIZED CAPSULE FORMULATION OF 1,1-DIMETHYLETHYL [(1S)-1- [(2S,4R)-4-(7-CHLORO-4METHOXYISOQUINOLIN-1-YLOXY)-2-((1R,2S)-1- [(CYCLOPROPYLSULFONYL)CARBAMOYL]-2- ETHENYLCYCLOPROPYLCARBAMOYL)PYRROLIDIN-1-YL]CARBONYL-2,2- DIMETHYLPROPYL]CARBAMATE [(1S)-1-[(2S4R)-4-(7--4--1-)-2-((1R2S)-1- [()]-2-)-1-]- 22-] 11-

摘要

The present disclosure includes various embodiments directed to a solubilized capsule formulation of asunaprevir, 1,1-dimethylethyl[(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate, and to methods including asunaprevir.