| 摘要 |
The disclosure relates to a family of compounds that fall within general Formula IV. These are modified nucleosides and nucleoside phosphates that contain an imidazo[1,2-f][1,2,4]triazinyl moiety. The 2’ position of the cyclic nucleoside sugar (which has a tetrahydrofuran structure) is substituted with halogen (R1) and carbon substituents (R2). R7 may be substituted with phosphate groups which may optionally also bind to the sugar via R3 or R5. The compounds are useful for the treatment of virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV. The disclosure also describes pharmaceutical compositions containing these compounds and methods to use them. |
