| 发明名称 |
METHODS OF PRODUCING IMMUNOCONJUGATES |
| 摘要 |
The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods. |
| 申请公布号 |
US2015337040(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
US201314654384 |
申请日期 |
2013.12.19 |
| 申请人 |
MEDIMMUNE, LLC |
发明人 |
HUNTER Alan;LINKE Thomas;PABST Timothy;WENDELER Michaela;WANG Xiangyang;THOMPSON Christopher;XI Guoling;FULTON Andrew |
| 分类号 |
C07K16/28;C07K1/36;C07K1/113;C07K16/30;C07K14/21 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing an active immunoconjugate, wherein said immunoconjugate is composed of two polypeptide chains joined by a disulfide bond, the method comprising refolding said immunoconjugate in a fed-batch refolding process and purifying the refolded immunoconjugate on one or more chromatography columns. |
| 地址 |
Gaithersburg MD US |
