| 发明名称 |
PROCESS FOR THE PREPARATION OF UNSATURATED TRIFLUOROMETHANESULFONATE STEROID DERIVATIVES |
| 摘要 |
Disclosed is a method for the conversion of a compound of formula 3 to a compound;;of formula 4, wherein R is an acetyl group or an alcohol-protecting group. The process involves reacting 3 with a triflating agent in the presence of a nicotinate (3-pyridinecarboxylate) of a C1-C4 alcohol, preferably methyl nicotinate (methyl 3-pyridinecarboxylate) or ethyl nicotinate (ethyl 3-pyridinecarboxylate), to give 4. The method can be conveniently used in a process for the preparation of Abiraterone or Abiraterone acetate. |
| 申请公布号 |
US2015337007(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
US201514713314 |
申请日期 |
2015.05.15 |
| 申请人 |
OLON S.P.A. |
发明人 |
Alpegiani Marco;Cristiano Tania |
| 分类号 |
C07J75/00 |
主分类号 |
C07J75/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Process for the conversion of a compound of formula 3, wherein R is an acetyl group or an alcohol-protecting group, to a compound of formula 4 wherein R is as defined above, comprising the reaction of 3 with a triflating agent in the presence of a C1-C4 alkyl nicotinate (3-pyridinecarboxylate). |
| 地址 |
Rodano IT |
