COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS

摘要

This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.

主权项

1. A composition comprising:
the compound of Formula I or pharmaceutically acceptable salts thereof; and, a buffer selected from the group consisting of citrate and succinate from about 10 mM to about 50 mM, wherein the composition is substantially free of saline and stable when exposed to room temperature for 60 or more days.