发明名称 |
METHOD FOR MONOMERIZING MATRIX METALLOPROTEINASE-7 (MMP-7) AGGREGATE |
摘要 |
Provided is a method for monomerizing an MMP-7 aggregate. An MMP-7 monomerization method comprising treating an MMP-7 aggregate with a buffer solution including a low concentration of a monovalent cation chloride (such as sodium chloride, potassium chloride, etc.), or with said buffer solution not including a monovalent cation chloride. An MMP-7 preparation method incorporating said monomerization method, and a (pharmaceutical) composition containing MMP-7 dissolved in said buffer solution. When preparing a (pharmaceutical) composition containing a low concentration of MMP-7, said buffer solution is used with a sugar alcohol or sugar added. |
申请公布号 |
WO2015178414(A1) |
申请公布日期 |
2015.11.26 |
申请号 |
WO2015JP64451 |
申请日期 |
2015.05.20 |
申请人 |
THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
NAKATAKE, HIROSHI;HIRASHIMA, MASAKI;TAKEO, HIDEKI;MATSUYAMA, REIKO;MORIKAWA, WATARU |
分类号 |
C12N9/64;A61K38/46;A61K47/02;A61K47/10;A61K47/16;A61K47/26;A61P19/00;A61P25/00;C12N9/96 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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