Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
申请公布号
CA2949681(A1)
申请公布日期
2015.11.26
申请号
CA20152949681
申请日期
2015.05.19
申请人
RQX PHARMACEUTICALS, INC.;GENENTECH, INC.
发明人
SCHWARZ, JACOB BRADLEY;LY, CUONG;CRAWFORD, JAMES;ROBERTS, TUCKER CURRAN;SMITH, PETER ANDREW;HIGUCHI, ROBERT I.;PARASELLI, PRASUNA;BERGERON, PHILIPPE;KOEHLER, MICHAEL F. T.;HU, HUIYONG