| 摘要 |
The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. Methods for prevention and treatment of neurological disorders, including, for example, seizures and seizure disorders, including Lennox-Gastaut Syndrome, Dravet syndrome, epileptic encephalopathies, autism, Familial hemiplegic migraine (FHM), anxiety disorders, including Post-traumatic stress disorder (PTSD), panic disorder and obsessive-compulsive disorder, neuropathic pain, and Rett syndrome by administration of these compounds are also provided. |
| 主权项 |
1. A compound of formula I: or a salt, solvate, or stereoisomer thereof, or a salt, solvate, or stereoisomer thereof, wherein X is H, or one or more electron withdrawing groups such as a halogen, NH2, NO2, SO2, CN, or a C1-C6 alkyl group; Alk is C1-C3 alkyl; R1 is H, C1-C6 alkyl, which may be substituted with OH, NH2, alkylamino, amido, acyl, sulfonyl, sulfonylamino, and cyano groups; R2, is C1-C6 alkyl, alkenyl, and phenyl, which may be substituted with one or more OH, NH2, alkylamino, amido, acyl, carboxyl, methoxyl, sulfonyl, and cyano groups; and wherein the compounds are selected from the group consisting of: or a salt, solvate, or stereoisomer thereof. |
