发明名称 Mutant bacterial glycoproteins and uses thereof
摘要 The present invention relates to the use of mutant glycoproteins from pathogenic bacteria lacking one or more phosphorylcholine and/or glycosylation post-translational modifications as immunogens. These post-translational modifications act as masking structures that elicit an immune response which does not confer protection on an infected individual. The removal or modification of these masking structures alters the protein such that it elicits a stronger immune response to the protein and/or the bacterial pathogen. Particular examples are pilin proteins and nitrite reductase glycoproteins of
申请公布号 AU2009287339(B2) 申请公布日期 2015.11.26
申请号 AU20090287339 申请日期 2009.08.28
申请人 THE UNIVERSITY OF QUEENSLAND 发明人 JENNINGS, MICHAEL PAUL
分类号 C07K14/195;C07K14/22 主分类号 C07K14/195
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