MODULATION OF FACTOR 11 EXPRESSION

摘要

PROBLEM TO BE SOLVED: To provide methods, compounds and compositions for reducing expression of Factor 11 mRNA and protein.SOLUTION: Disclosed herein an antisense compound to be used in an individual in need of treatment or prevention of thromboembolic complications by decreasing Factor 11. The compound comprises a modified oligonucleotide consisting of 12-30 linked nucleosides that targets Factor 11 nucleic acid, where the modified oligonucleotide has a nucleic acid sequence at least 90% complementary to the same length portion of Factor 11 nucleic acid. The antisense compound targeting Factor 11 is used as a prophylactic agent to prevent an individual at risk from thrombosis and embolism.