BIOCOMPATIBLE POLYMER COMPOSITIONS FOR TISSUE VOID FILLING

摘要

Biodegradable, bioabsorbable cross-linked polymer tissue scaffolds for filling a void in human or animal soft tissue, such as a surgical or other wound, are disclosed. Drugs incorporated into the polymer backbone and/or loaded into the matrix are released directly to the target site. Additional non-toxic chemical constituents can be used to tune the hydrophilio hydrophobic and other physical properties of the cross-linked polymer tissue scaffolds, and incorporating brominated or iodinated constituents provides radio-opacity. The radio-opaque cross-linked polymer tissue scaffolds can assist in the targeting of radiation therapy.

主权项

1. A biodegradable, bioabsorbable cross-linked polymer tissue scaffold composition for filling a void in soft tissue, which composition comprises a cross-linked polymer, wherein said polymer comprises one or more diphenol monomers at least one of which comprises curcumin, and one or more hydrophilic monomers, in a molar ratio of diphenol monomers to hydrophilic monomers between about 25:75 and about 75:25, wherein said curcumin is released as said cross-linked polymer tissue scaffold biodegrades.