| 发明名称 |
ANTITUMOR AGENT |
| 摘要 |
The invention provides a method of inhibiting binding between acetylated histone and a bromodomain-containing protein in a mammal, as well as a method of shrinking or killing of cancer cells expressing a bromodomain-containing protein or inhibiting the growth of cancer cells expressing a bromodomain-containing protein in a mammal. The methods involve administering an effective amount of (S)-2-[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide or a dihydrate thereof to the mammal. |
| 申请公布号 |
US2015335656(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
US201514819121 |
申请日期 |
2015.08.05 |
| 申请人 |
Mitsubishi Tanabe Pharma Corporation |
发明人 |
MIYOSHI Shinji;OOIKE Shinsuke;IWATA Kazunori;HIKAWA Hidemasa;SUGAHARA Kunio |
| 分类号 |
A61K31/551 |
主分类号 |
A61K31/551 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of inhibiting the growth of cancer cells in a mammal, comprising administering an effective amount of (S)-2-[4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide dihydrate thereof to the mammal. |
| 地址 |
Osaka-shi JP |
