SIGNAL PROPAGATION BIOMOLECULES, DEVICES, AND METHODS
摘要
This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.
申请公布号
WO2015179619(A1)
申请公布日期
2015.11.26
申请号
WO2015US31938
申请日期
2015.05.21
申请人
STC.UNM;BROWN III, CARL;GRAVES, STEVEN, WAYDE;STEFANOVIC, DARKO;LAKIN, MATTHEW, RICHARD
发明人
BROWN III, CARL;GRAVES, STEVEN, WAYDE;STEFANOVIC, DARKO;LAKIN, MATTHEW, RICHARD