发明名称 |
Rationally-Designed Single-Chain Meganucleases With Non-Palindromic Recognition Sequences |
摘要 |
Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases. |
申请公布号 |
US2015337335(A1) |
申请公布日期 |
2015.11.26 |
申请号 |
US201514723840 |
申请日期 |
2015.05.28 |
申请人 |
PRECISION BIOSCIENCES, INC. |
发明人 |
SMITH James Jefferson;JANTZ Derek |
分类号 |
C12N15/90;C12N9/16 |
主分类号 |
C12N15/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Durham NC US |