| 发明名称 |
Colon and Pancreas Cancer Peptidomimetics |
| 摘要 |
The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods. |
| 申请公布号 |
US2015337023(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
US201514725477 |
申请日期 |
2015.05.29 |
| 申请人 |
Precision Biologics, Inc. |
发明人 |
Wang Xue-Ping |
| 分类号 |
C07K14/47;A61K39/00;A61K45/06;A61K47/48 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated polypeptide comprising a polypeptide at least about 80% identical to the amino acid sequence of SX1PX2DX3FRYX4NX5 (SEQ ID NO: 1), wherein X1 is for L; X2 is E or D; X3 is Y or W; X4 is T or I and X5 is Q or Y; SX1PX2DX3FRYX4NX5K (SEQ ID NO: 2), wherein X1 is for L; X2 is E or D; X3 is Y or W; X4 is T or I and X5 is Q or Y; SLEPEX1DWX2FRYX3NY (SEQ ID NO: 3), wherein X1 is E or D; X2 is W or Y; and X3 is T or I; FPEDYFRYTNQK (SEQ ID NO: 4); SLPDDWFRYINY (SEQ ID NO: 5); or any one of the amino acid sequences of SEQ ID NOs: 6-24. |
| 地址 |
Rockville MD US |
