发明名称 THERAPEUTIC SUBSTITUTED PYRROLES
摘要 Disclosed herein are compounds of the formula:;;compositions thereof, and methods for the treatment of glaucoma, reducing intraocular pressure, and other prostaglandin EP2 mediated disease and disorders.
申请公布号 US2015336940(A1) 申请公布日期 2015.11.26
申请号 US201514716478 申请日期 2015.05.19
申请人 Allergan, Inc. 发明人 Old David W.
分类号 C07D409/06;A61Q7/00;A61Q5/00;A61K8/49 主分类号 C07D409/06
代理机构 代理人
主权项 1. A compound represented by the formula:or a pharmaceutically acceptable salt thereof, wherein Y is C0-14H1-30O1-4S0-2N0-4P0-1 and is: an organic acid functional group, or an amide or ester thereof; hydroxymethyl or an ether thereof; or a tetrazolyl functional group; A is —(CH2)5—, —CH═CH(CH2)3—, or —C≡C(CH2)3—, wherein: a) 1 or 2 —CH2— may be replaced with —O— or —S—, orb) —CH2CH2—, —(CH2)3—, or —(CH2)4— is replaced by —Ar— and 1 —CH2— may be replaced by —O— or —S—, Ar is aryl of a formula C3-10H0-23N0-4O0-4S0-4F0-5Cl0-3Br0-3I0-3, R1, R2, and R3 are independently —H, —F, —Cl, —Br, —I, or a moiety of a formula C0-6H0-14N0-1O0-2S0-1. B is aryl of a formula C5-20H0-45N0-4O0-4S0-4F0-5Cl0-3Br0-3I0-3.
地址 Irvine CA US