| 发明名称 |
MULTIPARTICLES SAFEGUARDED AGAINST ETHANOLIC DOSE-DUMPING |
| 摘要 |
The invention relates to an oral pharmaceutical dosage form providing resistance against dose dumping in aqueous ethanol and comprising a pharmacologically active ingredient embedded in a matrix material,
wherein the matrix material comprises an alkyl cellulose and a heteropolysaccharide; andwherein the relative weight ratio of heteropolysaccharide to alkyl cellulose is within the range of from 1:20 to 20:1; and
wherein the total content of alkyl cellulose and heteropolysaccharide is at least 35 wt.-%, relative to the total weight of the dosage form. A process of producing the dosage form and methods of using the dosage form, for example to treat pain, are also disclosed. |
| 申请公布号 |
US2015335592(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
US201514719351 |
申请日期 |
2015.05.22 |
| 申请人 |
GRÜNENTHAL GMBH |
发明人 |
BARNSCHEID LUTZ;WENING KLAUS;PÄTZ JANA;GEISSLER ANJA |
| 分类号 |
A61K31/135;A61K9/16;A61K9/48 |
主分类号 |
A61K31/135 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An oral pharmaceutical dosage form providing resistance against dose dumping in aqueous ethanol and comprising a pharmacologically active ingredient embedded in a matrix material,
wherein the matrix material comprises an alkyl cellulose and a heteropolysaccharide; and wherein the relative weight ratio of heteropolysaccharide to alkyl cellulose is within the range of from 1:20 to 20:1; and wherein the total content of alkyl cellulose and heteropolysaccharide is at least 35 wt.-%, relative to the total weight of the dosage form. |
| 地址 |
AACHEN DE |
