System and Method for a Biomimetic Fluid Processing

摘要

A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.

主权项

1. A biomimetic microfluidic system comprising:
a substrate; a first channel formed in the substrate, the first channel extending from a first input to a first output and along a longitudinal dimension and extending along a first transverse dimension; a second channel formed in the substrate, the second channel extending from a second input to a second output along the longitudinal dimension and extending along a second transverse dimension, wherein the first and second channels extend substantially parallel; a series of gaps extending from the first channel to the second channel to create a fluid communication path passing between a series of columns, the columns being longitudinally separated by a predetermined separation distance; a first source connected to the first input, the first source configured to selectively introduce into the first channel at least one first biological composition at a first channel flow rate; and a second source connected to the second input, the second source configured to selectively introduce into the second channel at least one second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates along the second channel bounded within a predetermined range and to influence the flow within the first channel through the series of gaps.