| 摘要 |
The activity of certain antibiotics which function by binding to the r50S ribosomal subunit of bacterial r70s ribosome to inhibit prokaryotic ribosomal translocation, my be increased by certain substrates of a certain subclass of CYP450, i.e., CYP450 oxidases found in vivo in human smooth endoplasmic reticulum. Combining a suitable CYP450 substrate with a suitable antibiotic may thus increase the efficacy of the antibiotic, without increasing the dose and thus avoiding adverse side effects appurtenant to high dose antibiotic therapy. |
