| 摘要 |
PROBLEM TO BE SOLVED: To provide a therapeutic method that is useful to treat glaucoma or elevated intraocular pressure.SOLUTION: Phosphodiesterase 1 (PDE1) inhibitors expressed by formula III are administered, and the inhibitors are administered in combination with intraocular pressure-lowering agents, wherein Rand Rare each independently H or Calkyl; Rand Rare each independently H, Calkyl, aryl, heteroaryl, arylalkoxy, heteroarylalkoxy, heteroarylalkyl, or arylalkyl; or Ris H and Rand Rtogether form a di-, tri- or tetramethylene bridge; Ris a substituted heteroarylalkyl or heteroarylmethylene attached to N on a pyrazolo portion; Ris H, alkyl, aryl, heteroaryl, and the like; and n=0 or 1, when n=1, A is -C(RR)- . |
