Compositions and Methods for Diagnosing and Assessing Inflammatory Myopathies

摘要

The present invention is directed to assay methods for inflammatory myopathies and microarray plates that can be used in carrying out these assays.

主权项

1. A method of determining whether a subject exhibits a gene expression pattern characteristic of polymyositis or dermatomyositis, comprising:
a) obtaining a test biological sample from said subject containing peripheral blood mononuclear cells; b) assaying said sample for the expression of one or more genes selected from the group consisting of: interferon alpha-inducible protein 27; interferon-induced protein 44-like; radical S-adenosyl domain/CIGS; interferon-induced protein 44; hypothetical protein LOC129607; 2′,5′-oligoadenylate synthetase 1; epithelial stromal interaction 1; XIAP associated factor-1; interferon-induced tetratricopeptide 5; 2′-5′-oligoadenylate synthetase-like; 2′-5′-oligoadenylate synthetase 3; interferon-induced tetratricopeptide 1; phospholipid scramblase 1; hect domain and RLD 5; interferon-inducible protein kinase; TNF superfamily, member 10; guanylate binding protein 1; TNF, alpha-induced protein 6; interferon-induced tetratricopeptide 3; sterile alpha motif domain 9-like; chromatin modifying protein 5; ISG15 ubiquitin-like modifier; 2′-5′-oligoadenylate synthetase 2; interferon induced helicase C domain 1; and myxovirus resistance 1; c) concluding that said subject has a gene expression profile characteristic of polymyositis or dermatomyositis if the results determined in the assay of paragraph b) indicate that one or more of said genes are expressed more highly in said test sample than in one or more control samples.