SUPERSATURATED STABILIZED NANOPARTICLES FOR POORLY SOLUBLE DRUGS

摘要

A pharmaceutical composition and method of producing supersaturated stabilized nanoparticles of poorly soluble drugs having average sizes less than 1 μm, or less than 800 nm, or less than 500 nm, comprising at least one pharmaceutically active ingredient, a hydrophilic polymer, a water-soluble surfactant, and subsequently stabilized by ionic polymers.

主权项

1. A stabilized nanosuspension comprising:
a) an aqueous solution comprising a water-soluble surfactant and a water-soluble polymer, wherein particles of a pharmaceutically active ingredient are suspended within said aqueous solution; and b) combining a de-agglomeration agent with said aqueous solution, wherein said de-agglomeration agent maintains an average size of said particles of less than about 800 nm;and wherein said de-agglomeration agent maintains a supersaturated concentration of said pharmaceutically active ingredient above a solubility of said pharmaceutically active ingredient in said nanosuspension.