发明名称 |
ANTIBODIES THAT BIND HUMAN CD27 AND USES THEREOF |
摘要 |
Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies. |
申请公布号 |
US2015337047(A1) |
申请公布日期 |
2015.11.26 |
申请号 |
US201514790247 |
申请日期 |
2015.07.02 |
申请人 |
Celldex Therapeutics, Inc. |
发明人 |
KELER Tibor;MARSH Henry C.;HE Lizhen;VITALE Laura A.;THOMAS Lawrence J. |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. A method for inducing or enhancing an immune response against an antigen in a subject comprising administering to the subject a monoclonal antibody which binds to human CD27, in an amount effective to induce or enhance an immune response against an antigen, wherein the antibody comprises a heavy chain variable region CDR1 comprising SEQ ID NO: 38; a heavy chain variable region CDR2 comprising SEQ ID NO: 39; a heavy chain variable region CDR3 comprising SEQ ID NO: 40; a light chain variable region CDR1 comprising SEQ ID NO: 44; a light chain variable region CDR2 comprising SEQ ID NO: 45; and a light chain variable region CDR3 comprising SEQ ID NO: 46. |
地址 |
Needham MA US |