发明名称 |
HUMAN ANTIBODIES TO MIDDLE EAST RESPIRATORY SYNDROME - CORONAVIRUS SPIKE PROTEIN |
摘要 |
The present invention provides monoclonal antibodies that bind to the Middle East Respiratory Syndrome - Coronavirus (MERS-CoV) spike protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that bind to MERS-CoV spike protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing MERS-CoV activity, thus providing a means of treating or preventing MERS infection in humans. In some embodiments, the invention provides for a combination of one or more antibodies that bind to the MERS-CoV spike protein for use in treating MERS infection. In certain embodiments, the one or more antibodies bind to distinct non-competing epitopes comprised in the receptor binding domain of the MERS-CoV spike protein. |
申请公布号 |
CA2949438(A1) |
申请公布日期 |
2015.11.26 |
申请号 |
CA20152949438 |
申请日期 |
2015.05.20 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
KYRATSOUS, CHRISTOS;STAHL, NEIL;SIVAPALASINGAM, SUMATHI |
分类号 |
C07K16/10;A61K39/42;A61P31/14;C12N15/13;C12P21/08 |
主分类号 |
C07K16/10 |
代理机构 |
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代理人 |
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地址 |
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