Liquid Formulations of Bendamustine

摘要

Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.

主权项

1. A stable, non-aqueous, liquid formulation comprising from about 5 mg/mL to about 200 mg/mL of bendamustine or a pharmaceutically acceptable salt thereof, and up to about 90% of a mixture of polyethylene glycol and propylene glycol wherein said formulation contains not less than 95% of the amount of bendamustine present prior to exposure to storage conditions that include a temperature of about 5° C. and a time period of about 180 days.