发明名称 |
OXAZOLIDONE COMPOUNDS, METHOD FOR PREPARING AND APPLICATION THEREOF |
摘要 |
The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a diastereoisomer and a raceme thereof, and a mixture thereof, and a pharmaceutically acceptable salt thereof, a preparation method thereof, an application thereof as a bioactive substance in a drug. The compound in the present invention has strong anticoagulant activity, does not affect the activity of thrombin, and can reduce the risk of hemorrhage. A pharmacokinetics experiment shows that the compound in the present invention further has good metabolic characteristics, and has a far better oral bioavailability than a positive contrastive agent rivaroxaban. |
申请公布号 |
EP2947085(A1) |
申请公布日期 |
2015.11.25 |
申请号 |
EP20130872046 |
申请日期 |
2013.12.30 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;ZHE JIANG JUTAI PHARMACEUTICAL CO., LTD |
发明人 |
YANG, YUSHE;XUE, TAO;DING, SHI;GUO, BIN |
分类号 |
C07D498/04;A61K31/5383;A61P7/02;C07D519/00 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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