发明名称 |
INDOLECARBOXAMIDE DERIVATIVE |
摘要 |
[Problem] To provided a compound which is useful as an MT1 and/or MT2 receptor agonist. [Means for Solution] The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the MT1 and/or MT2 receptor agonistic action as well as a low CNS penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like. |
申请公布号 |
EP2873660(A4) |
申请公布日期 |
2015.11.25 |
申请号 |
EP20130816547 |
申请日期 |
2013.07.09 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
KANAYAMA, TAKATOSHI;KUBOTA, HIDEKI;MATSUMOTO, SHUNICHIRO;SAITO, TOMOYUKI;SHIMIZU, TAKAFUMI;KATOH, NAOTO;MATSUI, SHIGEO |
分类号 |
C07D209/42;A61K31/4045;A61K31/407;A61K31/437;A61P13/10;C07D471/04;C07D491/048 |
主分类号 |
C07D209/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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