发明名称 INDOLECARBOXAMIDE DERIVATIVE
摘要 [Problem] To provided a compound which is useful as an MT1 and/or MT2 receptor agonist. [Means for Solution] The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the MT1 and/or MT2 receptor agonistic action as well as a low CNS penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like.
申请公布号 EP2873660(A4) 申请公布日期 2015.11.25
申请号 EP20130816547 申请日期 2013.07.09
申请人 ASTELLAS PHARMA INC. 发明人 KANAYAMA, TAKATOSHI;KUBOTA, HIDEKI;MATSUMOTO, SHUNICHIRO;SAITO, TOMOYUKI;SHIMIZU, TAKAFUMI;KATOH, NAOTO;MATSUI, SHIGEO
分类号 C07D209/42;A61K31/4045;A61K31/407;A61K31/437;A61P13/10;C07D471/04;C07D491/048 主分类号 C07D209/42
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