发明名称 |
REPROGRAMMING OF HUMAN ENDOTHELIUM INTO HEMATOPOIETIC MULTI-LINEAGE PROGENITORS BY DEFINED FACTORS |
摘要 |
The invention is directed to generation of hematopoietic multi-lineage progenitors (HMLPs) from endothelial cells (ECs) by effecting forced expression of certain transcription factors in the ECs and culturing the ECs in serum free media in the presence of endothelial feeder cells. The HMLPs generated in accordance with this invention can produce erythroid, lymphoid, myeloid, and megakaryocyte cells. These generated HMLPs can be used in therapeutic treatment of disorders including hematopoietic conditions. |
申请公布号 |
EP2946007(A1) |
申请公布日期 |
2015.11.25 |
申请号 |
EP20140740745 |
申请日期 |
2014.01.15 |
申请人 |
CORNELL UNIVERSITY |
发明人 |
SANDLER, VLADISLAV M.;RAFII, SHAHIN |
分类号 |
C12N5/02;A61K35/12;A61P7/00;A61P35/02;C12N5/071;C12N5/0775;C12N5/078;C12N5/0789 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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